Research Areas

1. Prototyping and fabrication of an integrated plate system with pillars and perfusion wells
2. Synthesis of tunable hydrogels (“bioink”) for miniature 3D bioprinting
3. Development of microscale 3D human cell printing technology on pillar/perfusion plate platforms for tissue engineering and disease modeling
   • Liver, intestine, and pancreas organoid culture for modeling type II diabetes
   • Brain organoid culture for developmental toxicology
   • Gene-edited liver organoid culture for disease modeling and predictive drug screening
   • Gene-edited intestine organoid culture for predictive pharmacokinetics studies
   • Liver tumor organoid culture from biopsy samples for personalized cancer therapy
   • Multi-organoid co-culture on pillar/perfusion plates for disease modeling
4. Establishment of high-content imaging (HCI) assays on 3D-cultured human cells
5. Development of viral gene delivery systems to study individual-dependent, adverse drug responses
6. Development of predictive assays to assess the efficacy of antimicrobial agents

Microarray Chip Platforms

3D Cell/Tissue Culture on 384PillarPlate

Commercial Applications of Miniaturized Human Tissue Constructs

• Predictive assessment of drug toxicity, efficacy, and pharmacokinetics for preclinical evaluations on bioprinted tissue constructs
• Human disease modeling on bioprinted tissue constructs
• Systematic study of cellular microenvironments for tissue engineering and regenerative medicines
• High-throughput, high-content screening of drug candidates and environmental toxicants

Applications of Microarray Biochips